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Description Erythema multiforme major, also referred to as Stevens-Johnson syndrome, is a toxic or allergic rash in response to the smallpox vaccine that can take various forms, and range from moderate to severe. This image was created in 08/2003 and provided by the Centers for Disease Control and Prevention/Allen W. Mathies, MD, John Leedom, MD/ California Emergency Preparedness Office (Calif/EPO), Immunization Branch. For any questions about these photos, e-mail rschecht@dhs.ca.gov.
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